Corpus ID: 2425555

CD43 diminishes susceptibility to T lymphocyte-mediated cytolysis.

@article{McFarland1995CD43DS,
  title={CD43 diminishes susceptibility to T lymphocyte-mediated cytolysis.},
  author={T A McFarland and Blair M. Ardman and Narasimhaswamy Manjunath and J A Fabry and Judy Lieberman},
  journal={Journal of immunology},
  year={1995},
  volume={154 3},
  pages={
          1097-104
        }
}
CD43 is a major membrane sialoglycoprotein expressed by cells of hematopoietic origin. One property of CD43 is its ability to interfere with heterotypic and homotypic cellular adhesion. To determine whether CD43 expression can affect cell functions requiring intercellular adhesion, we compared a CD43-positive human T cell line (CEM) and its CD43-negative counterpart derived by gene targeting for susceptibility to cell-mediated lysis. CD43-negative CEM cells were more susceptible than CD43… Expand
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References

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CD43 interferes with T-lymphocyte adhesion.
TLDR
The data suggest that CD43 might regulate T-cell adhesion by interfering with leukocyte function-associated 1 binding to intercellular adhesion molecule 1, a major activation-induced adhesion pathway among lymphocytes. Expand
Targeted disruption of CD43 gene enhances T lymphocyte adhesion.
TLDR
The data suggest that CD 43 interferes with T lymphocyte adhesion and that CD43 can regulate lymphocyteAdhesion by providing a threshold that must be overcome for cell-cell and cell-ligand interactions to occur. Expand
Enhancement of T-cell activation by the CD43 molecule whose expression is defective in Wiskott–Aldrich syndrome
TLDR
It is observed that CD43 enhances the antigen-specific activation of T cells and that the intracellular domain of CD43, which is hyperphosphorylated during T-cell activation19–21, is required for this function. Expand
CD43, a molecule defective in Wiskott-Aldrich syndrome, binds ICAM-1
TLDR
Evidence that intercellular adhesion molecule-1 (ICAM-1, or CD54), is a ligand for CD43 is reported, indicating that the specific interaction of CD43 withA ligand on the surface of Daudi cells might contribute to T-cell activation. Expand
Induction of aggregation and enhancement of proliferation and IL-2 secretion in human T cells by antibodies to CD43.
TLDR
The results indicate that regulatory signals, which may function to modify homo- or heterotypic T cell adhesion as well as autocrine production of IL-2, can be transduced through CD43. Expand
The lymphocyte function-associated LFA-1, CD2, and LFA-3 molecules: cell adhesion receptors of the immune system.
TLDR
This review focuses on LFAI, CD2, and LFA-3, which appear to enhance antigen-specific functions by acting as cell adhesion molecules and the role of CD4 and CD8 is reviewed by Littman. Expand
Human neutrophils release their major membrane sialoprotein, leukosialin (CD43), during cell activation
TLDR
The shedding of such a strongly anionic and major membrane protein should drastically modify PMN surface charge and may allow previously hindered interactions by exposing new adhesion molecules. Expand
A monoclonal antibody to sialophorin (CD43) induces homotypic adhesion and activation of human monocytes
TLDR
The findings suggest that the surface molecule CD43 is the receptor of an independent activation pathway that leads in lymphocytes to proliferation and in monocytes to activation. Expand
Episialin (MUC1) inhibits cytotoxic lymphocyte-target cell interaction.
TLDR
It is concluded that over-expression of episialin as found on many tumor cells may indeed affect efficient lysis by cytotoxic lymphocytes and thus may contribute to escape from immune surveillance. Expand
Characterization of ICAM-2 and evidence for a third counter-receptor for LFA-1
TLDR
In an endeavor to further characterize human intercellular adhesion molecule-2 (ICAM-2), two murine monoclonal antibodies were generated and it is demonstrated that this putative third ligand for LFA-1 exists on SKW3 and other cell lines. Expand
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