CD40L-expressing CD8 T cells prime CD8alpha(+) DC for IL-12p70 production.

@article{Wong2008CD40LexpressingCT,
  title={CD40L-expressing CD8 T cells prime CD8alpha(+) DC for IL-12p70 production.},
  author={Kok Loon Wong and Fei Chuin Lew and Paul A MacAry and David M Kemeny},
  journal={European journal of immunology},
  year={2008},
  volume={38 8},
  pages={
          2251-62
        }
}
CD8alpha(+) DC are implicated as the principle DC subset for cross-presentation and cross-priming of cytotoxic CD8 T cell responses. In this study, we demonstrate another unique facet of the CD8alpha(+) DC and CD8 T cell relationship, by showing that CD8 T cells reciprocally activate CD8alpha(+) DC, but not CD8alpha(-) DC, for IL-12p70 production, the key Th1-promoting cytokine. This effect was observed during an antigen-specific interaction between DC and activated CD8 T cells, along with… CONTINUE READING
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