CD40L blockade prevents autoimmune encephalomyelitis and hampers TH1 but not TH2 pathway of T cell differentiation

@article{Samoilova1997CD40LBP,
  title={CD40L blockade prevents autoimmune encephalomyelitis and hampers TH1 but not TH2 pathway of T cell differentiation},
  author={Elena B. Samoilova and Jennifer L. Horton and Haidi Zhang and Yanfei Sun Xue Chen},
  journal={Journal of Molecular Medicine},
  year={1997},
  volume={75},
  pages={603-608}
}
 Although it is well established that CD40 and its ligand (CD40L) play pivotal roles in the development of humoral immunity, their roles in cell-mediated immunity and cell-mediated autoimmune diseases are not well defined. We report here that CD40:CD40L interaction is crucial for the development of experimental autoimmune encephalomyelitis (EAE), a prototype TH1-cell mediated autoimmune disease. Specific blockade of CD40L at the time of immunization markedly suppressed the incidence, mortality… CONTINUE READING

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