CD40L and Its Receptors in Atherothrombosis—An Update

  title={CD40L and Its Receptors in Atherothrombosis—An Update},
  author={Nathaly Anto Michel and Andreas Zirlik and Dennis Wolf},
  booktitle={Front. Cardiovasc. Med.},
CD40L (CD154), a member of the tumor necrosis factor superfamily, is a co-stimulatory molecule that was first discovered on activated T cells. Beyond its fundamental role in adaptive immunity-ligation of CD40L to its receptor CD40 is a prerequisite for B cell activation and antibody production-evidence from more than two decades has expanded our understanding of CD40L as a powerful modulator of inflammatory pathways. Although inhibition of CD40L with neutralizing antibodies has induced life… CONTINUE READING
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