CD40L activation in circulating platelets in patients with acute coronary syndrome.

@article{Lee1999CD40LAI,
  title={CD40L activation in circulating platelets in patients with acute coronary syndrome.},
  author={Y C Lee and W H Lee and Shang C Lee and Kyu Joong Ahn and Yun Ha Choi and Seong Wook Park and Jung Don Seo and Jeong Euy Park},
  journal={Cardiology},
  year={1999},
  volume={92 1},
  pages={11-6}
}
The CD40-CD40L interaction, which was initially shown to have important roles in the T cell-mediated activation of B cells during humoral immune responses, is now known to have roles in activation of endothelial cells, smooth muscle cells, and macrophages within atherosclerotic plaques. Recently, CD40L expression was found in activated platelets in the thrombus in vivo and CD40L was reported to be responsible for the platelet-mediated activation of endothelial cells in vitro. To investigate the… CONTINUE READING