CD40L-Tri, a novel formulation of recombinant human CD40L that effectively activates B cells

  title={CD40L-Tri, a novel formulation of recombinant human CD40L that effectively activates B cells},
  author={Masayasu Naito and Ursula Hainz and Ute E. Burkhardt and Buyin Fu and Deborah Ahove and Kristen E. Stevenson and Mohini Rajasagi and Baogong Zhu and Anselmo Alonso and Elizabeth A Witten and Ken-ichi Matsuoka and Donna S Neuberg and Jonathan S Duke-Cohan and Catherine J. Wu and Gordon J Freeman},
  booktitle={Cancer Immunology, Immunotherapy},
CD40L has a well-established role in enhancing the immunostimulatory capacity of normal and malignant B cells, but a formulation suitable for clinical use has not been widely available. Like other TNF family members, in vivo and in vitro activity of CD40L requires a homotrimeric configuration, and growing evidence suggests that bioactivity depends on higher-order clustering of CD40. We generated a novel formulation of human recombinant CD40L (CD40L-Tri) in which the CD40L extracellular domain… CONTINUE READING
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