CD40-stimulated B lymphocytes pulsed with tumor antigens are effective antigen-presenting cells that can generate specific T cells.

@article{Lapointe2003CD40stimulatedBL,
  title={CD40-stimulated B lymphocytes pulsed with tumor antigens are effective antigen-presenting cells that can generate specific T cells.},
  author={R{\'e}jean Lapointe and Ang{\'e}lique Bellemare-Pelletier and Franck Housseau and Jacques Thibodeau and Patrick Hwu},
  journal={Cancer research},
  year={2003},
  volume={63 11},
  pages={2836-43}
}
Although they are considered as antigen-presenting cells, the role of antigen-unspecific B lymphocytes in antigen presentation and T-lymphocyte stimulation remains controversial. In this paper, we tested the capacity of normal human peripheral activated B cells to stimulate T cells using melanoma antigens or melanoma cell lysates. B lymphocytes activated through CD40 ligation and then pulsed with tumor antigens efficiently processed and presented MHC class II-restricted peptides to specific CD4… CONTINUE READING

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Modulation of the major histocompatibility complex class IIassociated peptide repertoire by human histocompatibility leukocyte antigen (HLA)DO

M. van Ham, M. van Lith, +10 authors J. Neefjes
J. Exp. Med., • 2000
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