CD40 signals apoptosis through FAN-regulated activation of the sphingomyelin-ceramide pathway.

  title={CD40 signals apoptosis through FAN-regulated activation of the sphingomyelin-ceramide pathway.},
  author={Bruno S{\'e}gui and Nathalie Andrieu-abadie and Sabine Adam-Klages and Olivier Meilhac and Dirk Kreder and Virginie Garcia and Alain P Bruno and J P Jaffr{\'e}zou and Robert Salvayre and M D Kurt Kroenke and Thierry Levade},
  journal={The Journal of biological chemistry},
  volume={274 52},
The possibility that the sphingomyelin (SM)-ceramide pathway is activated by CD40, a transmembrane glycoprotein belonging to the tumor necrosis factor receptor superfamily and that plays a critical role in the regulation of immune responses has been investigated. We demonstrate that incubation of Epstein-Barr virus-transformed lymphoid cells with an anti-CD40 antibody acting as an agonist results in the stimulation of a neutral sphingomyelinase, hydrolysis of cellular SM, and concomitant… CONTINUE READING


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