CD40 signaling replaces CD4+ lymphocytes and its blocking prevents chronic rejection of heart transplants.

Abstract

Chronic rejection remains the major obstacle to long term survival in heart transplant recipients. The cellular and molecular mechanisms that underlie chronic rejection are not known, and their discovery can form the basis of clinical intervention. Several investigators have suggested that the development of chronic rejection in solid organ transplants is… (More)

Topics

4 Figures and Tables

Slides referencing similar topics