CD40 ligation triggers COX-2 expression in endothelial cells: evidence that CD40-mediated IL-6 synthesis is COX-2-dependent

@article{DongariBagtzoglou2003CD40LT,
  title={CD40 ligation triggers COX-2 expression in endothelial cells: evidence that CD40-mediated IL-6 synthesis is COX-2-dependent},
  author={A Dongari-Bagtzoglou and Ulrich Thienel and Michael Jay Yellin},
  journal={Inflammation Research},
  year={2003},
  volume={52},
  pages={018-025}
}
Objective: To investigate whether CD40-CD154 interactions on HUVEC can trigger COX-2 synthesis as well as PGE2 and PGI2 secretion in vitro and explore whether the CD40-triggered prostanoids provide costimulatory signals for IL-6 secretion in this cell type.¶Materials and Methods: COX-2 protein expression was examined in HUVEC using Western blot analysis… CONTINUE READING