CD40 ligation results in protein kinase C-independent activation of ERK and JNK in resting murine splenic B cells.

@article{Li1996CD40LR,
  title={CD40 ligation results in protein kinase C-independent activation of ERK and JNK in resting murine splenic B cells.},
  author={Yuhong Li and Mekhine Baccam and Stephen B Waters and Jeffrey E. Pessin and Gail A Bishop and Gary A Koretzky},
  journal={Journal of immunology},
  year={1996},
  volume={157 4},
  pages={1440-7}
}
CD40 is a 45- to 50-kDa transmembrane glycoprotein that plays an important role in B cell proliferation, survival, memory, and Ig isotype switching. How CD40 engagement couples to these distal events in B cell activation remains poorly understood. In this study, we have examined signal transduction events mediated by CD40 cross-linking in resting murine splenic B cells. In comparison to signaling via the B cell Ag receptor (BCR), CD40 cross-linking was less effective at activating protein… CONTINUE READING