CD40 ligand is required for protective cell-mediated immunity to Leishmania major.

  title={CD40 ligand is required for protective cell-mediated immunity to Leishmania major.},
  author={Kim A. Campbell and Pamela J. Ovendale and Mary K. Kennedy and William C. Fanslow and Steven G Reed and Charles R. Maliszewski},
  volume={4 3},
The CD40-CD40 ligand (CD40L) signaling process is a pivotal component of multiple immunoregulatory pathways. Although the role that CD40L plays in humoral immune responses is fairly well defined, its function(s) in cell-mediated responses in vivo has not been established. We investigated this issue by assessing the course of Leishmania major infection in CD40L knockout (CD40LKO) mice that were generated on a resistant background. In response to parasite challenge, CD40LKO mice developed… CONTINUE READING
Highly Cited
This paper has 287 citations. REVIEW CITATIONS

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 103 extracted citations

Assembly and Regulation of the CD40 Receptor Complex in Human B Cells

The Journal of experimental medicine • 1997
View 2 Excerpts
Highly Influenced

287 Citations

Citations per Year
Semantic Scholar estimates that this publication has 287 citations based on the available data.

See our FAQ for additional information.