CD40 ligand is required for protective cell-mediated immunity to Leishmania major.

@article{Campbell1996CD40LI,
  title={CD40 ligand is required for protective cell-mediated immunity to Leishmania major.},
  author={Kim A. Campbell and Pamela J. Ovendale and Mary K. Kennedy and William C. Fanslow and Steven G Reed and Charles R. Maliszewski},
  journal={Immunity},
  year={1996},
  volume={4 3},
  pages={
          283-9
        }
}
The CD40-CD40 ligand (CD40L) signaling process is a pivotal component of multiple immunoregulatory pathways. Although the role that CD40L plays in humoral immune responses is fairly well defined, its function(s) in cell-mediated responses in vivo has not been established. We investigated this issue by assessing the course of Leishmania major infection in CD40L knockout (CD40LKO) mice that were generated on a resistant background. In response to parasite challenge, CD40LKO mice developed… CONTINUE READING
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