CD40 ligand and interferon-γ induce an antimicrobial response against Mycobacterium tuberculosis in human monocytes.

@article{KlugMicu2013CD40LA,
  title={CD40 ligand and interferon-γ induce an antimicrobial response against Mycobacterium tuberculosis in human monocytes.},
  author={Georgiana M Klug-Micu and Steffen Stenger and Andrea Sommer and Philip T Liu and Stephan R. Krutzik and Robert L Modlin and Mario Fabri},
  journal={Immunology},
  year={2013},
  volume={139 1},
  pages={121-8}
}
The ability of T cells to activate antimicrobial pathways in infected macrophages is essential to host defence against many intracellular pathogens. Here, we compared the ability of two T-cell-mediated mechanisms to trigger antimicrobial responses against Mycobacterium tuberculosis in humans, CD40 activation and the release of interferon-γ (IFN-γ). Given that IFN-γ activates a vitamin D-dependent antimicrobial response, we focused on induction of the key components of this pathway. We show that… CONTINUE READING

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