CD40 ligand and MHC class II expression are essential for human peripheral B cell tolerance

@article{Herv2007CD40LA,
  title={CD40 ligand and MHC class II expression are essential for human peripheral B cell tolerance},
  author={Maxime Herv{\'e} and Isabelle Isnardi and Yen-shing Ng and James B Bussel and Hans D. Ochs and Charlotte Cunningham-Rundles and Eric Meffre},
  journal={The Journal of Experimental Medicine},
  year={2007},
  volume={204},
  pages={1583 - 1593}
}
Hyper-IgM (HIGM) syndromes are primary immunodeficiencies characterized by defects of class switch recombination and somatic hypermutation. HIGM patients who carry mutations in the CD40-ligand (CD40L) gene expressed by CD4(+) T cells suffer from recurrent infections and often develop autoimmune disorders. To investigate the impact of CD40L-CD40 interactions on human B cell tolerance, we tested by ELISA the reactivity of recombinant antibodies isolated from single B cells from three CD40L… CONTINUE READING