CD40-ligand (CD154) gene therapy for chronic lymphocytic leukemia.

  title={CD40-ligand (CD154) gene therapy for chronic lymphocytic leukemia.},
  author={William G Wierda and Mark J. Cantwell and Stephanie J Woods and Laura Z. Rassenti and Charles E. Prussak and Thomas J. Kipps},
  volume={96 9},
Chronic lymphocytic leukemia (CLL) cells can be made to express recombinant CD40-ligand (CD154) by transduction with a replication-defective adenovirus vector (Ad-CD154). Ad-CD154-transduced and bystander leukemia cells become highly effective antigen-presenting cells that can induce CLL-specific autologous cytotoxic T lymphocytes in vitro. This study investigated the immunologic and clinical responses to infusion of autologous Ad-CD154-CLL cells in patients with CLL. After a one-time bolus… CONTINUE READING


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