CD40 is necessary for activation of naïve T cells by a dendritic cell line in vivo but not in vitro.

@article{Haase2004CD40IN,
  title={CD40 is necessary for activation of na{\"i}ve T cells by a dendritic cell line in vivo but not in vitro.},
  author={Claus Haase and Birgitte Koch Michelsen and T N J\orgensen},
  journal={Scandinavian journal of immunology},
  year={2004},
  volume={59 3},
  pages={237-45}
}
The importance of CD40-CD40L interactions during CD4(+) T-cell activation has been extensively investigated over the years; however, it still remains questionable whether the interaction is a prerequisite for dendritic cell (DC)-mediated antigen-specific priming in vivo. Naïve CD4(+) T cells require two signals for proper activation and induction of… CONTINUE READING