CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation.

@article{Inwald2003CD40IC,
  title={CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation.},
  author={David Inwald and Alison McDowall and Mark Jason Peters and R. E. Callard and Nigel J Klein},
  journal={Circulation research},
  year={2003},
  volume={92 9},
  pages={1041-8}
}
CD40 is a 48-kDa phosphorylated transmembrane glycoprotein belonging to the TNF receptor superfamily. CD40 has been demonstrated on a range of cell types, and it has an important role in adaptive immunity and inflammation. CD40 has recently been described on platelets but platelet activation by CD40 has not been described. In the present study, we use flow cytometry and immunoblotting to confirm that platelets constitutively express surface CD40. CD40 mRNA was undetectable, suggesting that the… CONTINUE READING