CD40-induced aggregation of MHC class II and CD80 on the cell surface leads to an early enhancement in antigen presentation.

@article{Clatza2003CD40inducedAO,
  title={CD40-induced aggregation of MHC class II and CD80 on the cell surface leads to an early enhancement in antigen presentation.},
  author={Abigail Clatza and Laura C. Bonifaz and Dario Angelo Alberto Vignali and Jos{\'e} Ra{\'u}l Moreno},
  journal={Journal of immunology},
  year={2003},
  volume={171 12},
  pages={
          6478-87
        }
}
Ligation of CD40 on B cells increases their ability to present Ag and to activate MHC class II (MHC-II)-restricted T cells. How this occurs is not entirely clear. In this study we demonstrate that CD40 ligation on Ag-presenting B cells (APC) for a short period between 30 min and 3 h has a rapid, augmenting effect on the ability of a B cell line and normal B cells to activate T cells. This is not due to alterations in Ag processing or to an increase in surface expression of CD80, CD86, ICAM-1… CONTINUE READING
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