CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway.

Abstract

Studies in vivo have documented the importance of CD40-gp39 interactions in the development of T-dependent antibody responses to foreign and auto-antigens. In this report, we demonstrate that allograft rejection is also associated with strong induction of CD40 and gp39 transcripts. When treatment was initiated at the time of transplant, MR1, a mAb specific… (More)

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Cite this paper

@article{Larsen1996CD40gp39IP, title={CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway.}, author={Christopher P. Larsen and Donnell Alexander and Diane L Hollenbaugh and Evelyn Elwood and Stuart Ritchie and Alejandro Aruffo and Russell C Hendrix and Thomas Pearson}, journal={Transplantation}, year={1996}, volume={61 1}, pages={4-9} }