CD40 expression levels modulate regulatory T cells in Leishmania donovani infection.

@article{Martin2010CD40EL,
  title={CD40 expression levels modulate regulatory T cells in Leishmania donovani infection.},
  author={Sunil Martin and Reena Agarwal and Gopal Murugaiyan and Bhaskar Saha},
  journal={Journal of immunology},
  year={2010},
  volume={185 1},
  pages={551-9}
}
Dendritic cell (DC)-expressed CD40 is shown to play crucial roles in eliciting effector T cell responses, primarily the proinflammatory CD4(+) Th subsets and cytotoxic CD8(+) T cells that eliminate various infections and tumors, respectively. In contrast, DCs are also implied in the generation of regulatory T cells (Tregs) that counteract the functions of the proinflammatory Th subsets and exacerbate infections. However, the role of DC-expressed CD40 in the generation of Tregs is unknown. In… CONTINUE READING

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