CD40 employs p38 MAP kinase in IgE isotype switching.

@article{Brady2001CD40EP,
  title={CD40 employs p38 MAP kinase in IgE isotype switching.},
  author={K J Brady and Stephen N. Fitzgerald and Sigurður Ingvarsson and Carl A. K. Borrebaeck and Paul N Moynagh},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={289 1},
  pages={
          276-81
        }
}
IgE switching requires the prior induction of C epsilon germline transcripts which is mediated by the concerted binding of STAT-6 and NF kappa B to the C epsilon promoter. These transcription factors are regulated by IL-4 and CD40, respectively. However the latter can effect other signaling pathways and the present study explores the role of p38 MAPK in induction of C epsilon germline transcripts. CD40 and IL-4, both alone and in synergy, were initially shown to activate the C epsilon promoter… 
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Background Citations
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Methods Citations
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p38 Mitogen-activated Protein Kinase Regulates Interleukin-4-induced Gene Expression by Stimulating STAT6-mediated Transcription*
TLDR
Results show that p38 MAPK also provides a costimulatory signal for IL-4-induced gene responses by directly stimulating the transcriptional activation of STAT6.
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TLDR
It is shown that mice produced less IgE when they were depleted of the neurotransmitter norepinephrine before the administration of Ag, suggesting that at least one mechanism by which endogenous B cell activity in vivo is regulated by NE involves stimulation of the β2AR on the B cell alone to increase the level of IgE produced in a p38 MAPK- and sCD23-dependent manner.
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TLDR
Collectively, IL-10 and IL-4 use novel regulatory mechanisms for CD40-induced prostanoid synthesis in monocytes, thus suggesting a potential role for these cytokines in regulating T cell-induced inflammatory responses, including autoimmune diseases.
MAPK- and CD23-Dependent Manner Regulated by Norepinephrine in a p38 The Level of IgE Produced by a B Cell Is
TLDR
Data suggest that at least one mechanism by which endogenous B cell activity in vivo is regulated by NE involves stimulation of the (cid:1) 2 AR on the B cell alone to increase the level of IgE produced in a p38 MAPK-and sCD23-dependent manner.
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