CD40 and adenosine A2 receptor agonist-cyclic adenosine monophosphate rescue B-cell antigen receptor-induced apoptosis through independent pathways and converge to prevent caspase activation.

Abstract

BACKGROUND Antigen receptor ligation induces apoptosis of B lymphocytes, but the molecular mechanisms underlying induction of apoptosis remain unclear, although the growing family of IL-1beta-converting enzyme cysteine proteases (caspases) are recognized to be major effectors of cellular death. OBJECTIVE We sought to delineate and compare the rescue of B… (More)

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@article{Sakata2000CD40AA, title={CD40 and adenosine A2 receptor agonist-cyclic adenosine monophosphate rescue B-cell antigen receptor-induced apoptosis through independent pathways and converge to prevent caspase activation.}, author={Nobuhiro Sakata and H Kawasome and Nobuhisa Terada and Gary Leon Johnson and Erwin W. Gelfand}, journal={The Journal of allergy and clinical immunology}, year={2000}, volume={105 3}, pages={522-31} }