CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells.

@article{Schwabe2001CD40AN,
  title={CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells.},
  author={Robert F Schwabe and Bernd Schnabl and Yongho Kweon and David A. Brenner},
  journal={Journal of immunology},
  year={2001},
  volume={166 11},
  pages={
          6812-9
        }
}
Activated hepatic stellate cells (HSCs) are the main producers of extracellular matrix in the fibrotic liver and contribute to hepatic inflammation through the secretion of chemokines and the recruitment of leukocytes. This study assesses the function of CD40 on human HSCS: Activated human HSCs express CD40 in culture and in fibrotic liver, as determined by flow cytometry, RT-PCR, and immunohistochemistry. CD40 expression is strongly enhanced by IFN-gamma. Stimulation of CD40 with CD40 ligand… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 64 CITATIONS

FILTER CITATIONS BY YEAR

2002
2018

CITATION STATISTICS

  • 5 Highly Influenced Citations

  • Averaged 2 Citations per year over the last 3 years

Similar Papers

Loading similar papers…