CD40 Signaling Synergizes with TLR-2 in the BCR Independent Activation of Resting B Cells

Abstract

Conventionally, signaling through BCR initiates sequence of events necessary for activation and differentiation of B cells. We report an alternative approach, independent of BCR, for stimulating resting B (RB) cells, by involving TLR-2 and CD40--molecules crucial for innate and adaptive immunity. CD40 triggering of TLR-2 stimulated RB cells significantly… (More)
DOI: 10.1371/journal.pone.0020651

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Cite this paper

@inproceedings{Jain2011CD40SS, title={CD40 Signaling Synergizes with TLR-2 in the BCR Independent Activation of Resting B Cells}, author={Shweta Jain and Sathi Babu Chodisetti and Javed Naim Agrewala}, booktitle={PloS one}, year={2011} }