CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis.

@article{Gerritse1996CD40CD40LI,
  title={CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis.},
  author={Koen Gerritse and Jon D Laman and Randolph J. Noelle and Alejandro Aruffo and Jeffrey A. Ledbetter and Wim J. A. Boersma and E. P. Claassen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 6},
  pages={2499-504}
}
We investigated the role of CD40-CD40 ligand (CD40L) interactions in multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE). Activated helper T cells expressing CD40L (gp39) surface protein were found in MS patient brain sections, but not in brain tissue sections of normal controls or patients with other neurological disease. CD40L-positive cells were co-localized with CD40-bearing cells in active lesions (perivascular infiltrates). Most of these CD40-bearing cells proved to… CONTINUE READING
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