CD40/CD40L signaling and its implication in health and disease.

  title={CD40/CD40L signaling and its implication in health and disease.},
  author={Antonios Chatzigeorgiou and Maria Lyberi and Gregorios Chatzilymperis and Andrianos Nezos and Elli F Kamper},
  volume={35 6},
CD40, a transmembrane receptor of the tumor necrosis factor gene superfamily is expressed on a variety of cells, such as monocytes, B-cells, antigen presenting cells, endothelial, smooth muscle cells, and fibroblasts. The interaction between CD40 and CD40 ligand (CD40L) enhances the expression of cytokines, chemokines, matrix metalloproteinases, growth factors, and adhesion molecules, mainly through the stimulation of nuclear factor kappa B. The aim of this review is to summarize the molecular… CONTINUE READING

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