CD40, CD154, Bax and Bcl‐2 Expression in Sjögren's Syndrome Salivary Glands: a Putative Anti‐Apoptotic Role During its Effector Phases

@article{Ohlsson2002CD40CB,
  title={CD40, CD154, Bax and Bcl‐2 Expression in Sj{\"o}gren's Syndrome Salivary Glands: a Putative Anti‐Apoptotic Role During its Effector Phases},
  author={Maria Ohlsson and P{\'e}ter Szodoray and Lado Lako Loro and Anne Christine Johannessen and Roland Jonsson},
  journal={Scandinavian Journal of Immunology},
  year={2002},
  volume={56}
}
Sjögren's syndrome (SS) is an autoimmune rheumatic disorder characterized by chronic lymphocytic infiltration and decreased secretion in the salivary glands (SGs). For some time, apoptosis has been suggested to constitute the major mechanism for acinar epithelial destruction during the effector phases; however, this is still controversial. We have recently demonstrated that despite the expression of Fas and FasL, the incidence of apoptosis is not increased in SS patients compared with control… 
Novel role of CD40 in Fas-dependent apoptosis of cultured salivary epithelial cells from patients with Sjögren's syndrome.
TLDR
CD40 signals promote Fas-dependent death of SS salivary epithelial cells by down-regulating c-FLIP expression, which may explain their resistance to undergoing apoptosis in response to either anti-Fas or anti-CD40 mAb, despite their surface expression of both proteins.
Role of salivary gland epithelial cells in the differentiation and activation of T lymphocytes in primary Sjögren's syndrome
TLDR
It is demonstrated that the proportion of circulating CD4+ T cells expressing OX40 was elevated in patients with pSS and correlated with systemic disease activity, and suggests that Tfh, IL-21 and Ox40L might be therapeutic targets in pSS.
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TLDR
The findings suggest that the early immigrating lymphocytes may have been primed at a site remote from the glands before arriving via the blood to the gland tissue to form the characteristic foci in SS/LSG.
Blocking T cell co-stimulation in primary Sjögren's syndrome: rationale, clinical efficacy and modulation of peripheral and salivary gland biomarkers.
TLDR
Although the discrepancies between biological and clinical efficacy of targeting T cell co-stimulation on pSS remain unresolved, several factors including drug bioavailability and receptor occupancy, patient stratification based on T-cell related biomarkers and the choice of study outcome are likely to play an important role and form the basis for further work towards the quest for a disease-modifying biologic therapy in pSS.
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TLDR
Many of the autoimmune mechanisms described above can be induced by type I interferon (IFN), and activation of this system in patients with Sjögren's syndrome has been described.
Epidermal growth factor inhibits Fas-mediated apoptosis in salivary epithelial cells of patients with primary Sjögren's syndrome.
TLDR
The results suggest that salivary epithelial cells are protected from Fas mediated apoptosis, through cell survival factors including either the PI3K-Akt pathway or NF-kB.
Programmed Cell Death of Peripheral Blood B Cells Determined by Laser Scanning Cytometry in Sjögren’s Syndrome with a Special Emphasis on BAFF
TLDR
BAFF induced a significant antiapoptotic effect in SS; also this effect was clearly evident in B cells from SS with hypergammaglobulinaemia, which indicates the disturbed B-cell biology in the disease.
B cells in Sjögren's syndrome: indications for disturbed selection and differentiation in ectopic lymphoid tissue
TLDR
Glandular B cells expressing distinct features of IgV light and heavy chain rearrangements, (re)circulating B cells with increased mutations of cμ transcripts in both CD27- and CD27+ memory B-cell subsets, and enhanced frequencies of individual peripheral B cells containing IgV heavy chain transcripts of multiple isotypes indicate disordered selection and incomplete differentiation processes of B cells in the inflamed tissues in pSS.
The Imbalance of Circulating Follicular T Helper Cell Subsets in Primary Sjögren’s Syndrome Associates With Serological Alterations and Abnormal B-Cell Distribution
TLDR
Imbalance in TFH subsets and TFR cells indicates an ongoing over-activated humoral immune response, which contributes to the characteristic serological manifestations and the pathogenesis of pSS.
Sjögren's syndrome (SjS)-like disease of mice: the importance of B lymphocytes and autoantibodies.
TLDR
An in-depth discussion of how B cell populations may be involved in orchestrating or determining exocrine gland dysfunction is presented.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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