CD4 regulatory T cells Control CD8 T cell responses to human Herpesvirus 8 lytic and latency proteins

Abstract

Methods Longitudinal PBMC samples were obtained from subjects with various outcomes of HHV-8 infection over many years in the Multicenter AIDS Cohort Study. The PBMC were tested by HLA A*0201 multimer staining specific for memory CD8 T cell epitopes of viral lytic and latency proteins, and polyfunctional flow cytometry to detect HHV8-specific, polyfunctional CD8 T cell populations. The effect of Treg was examined by depleting CD4CD25 cells.

DOI: 10.1186/1750-9378-7-S1-O17

Extracted Key Phrases

Cite this paper

@inproceedings{Lepone2012CD4RT, title={CD4 regulatory T cells Control CD8 T cell responses to human Herpesvirus 8 lytic and latency proteins}, author={Lauren M. Lepone and Giovanna Rappocciolo and Paolo A. Piazza and Mariel Jais and Frank J. Jenkins and Charles R. Rinaldo}, booktitle={Infectious Agents and Cancer}, year={2012} }