CD4-reactive antibodies in systemic lupus erythematosus.

  title={CD4-reactive antibodies in systemic lupus erythematosus.},
  author={Petar Lenert and G Lenert and J. L. Senecal},
  journal={Human immunology},
  volume={49 1},
An important place in the immune network is reserved for specific interactions between regulatory antibodies (Ab) and their ligands on T and B lymphocytes. Several lines of evidence indicate that the CD4 glycoprotein may be recognized by such Ab. High levels of CD4-reactive Ab occur in approximately 10-20% of HIV-infected patients. Moreover, between 20 and 30% SLE patients have Ab preferentially reactive with the CD4+ T cells. In relation to this, we have done studies aimed at demonstrating the… CONTINUE READING