CD4 lymphocytes in the blood of HIV(+) individuals migrate rapidly to lymph nodes and bone marrow: support for homing theory of CD4 cell depletion.

Abstract

The mechanism(s) by which human immunodeficiency virus (HIV) causes depletion of CD4 lymphocytes remains unknown. Evidence has been reported for a mechanism involving HIV binding to (and signaling) resting CD4 lymphocytes in lymphoid tissues, resulting in up-regulation of lymph node homing receptors and enhanced homing after these cells enter the blood, and… (More)

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@article{Chen2002CD4LI, title={CD4 lymphocytes in the blood of HIV(+) individuals migrate rapidly to lymph nodes and bone marrow: support for homing theory of CD4 cell depletion.}, author={Jenny J. Y. Chen and Jason C. Huang and Mark E. Shirtliff and Elma G Briscoe and Seham Ahmed Ali and Fernando Cesani and David P. Paar and Miles W. Cloyd}, journal={Journal of leukocyte biology}, year={2002}, volume={72 2}, pages={271-8} }