CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5

@article{Wu1996CD4inducedIO,
  title={CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5},
  author={Lijun Wu and Norma P. Gerard and Richard Wyatt and Hyeryun Choe and Cristina Parolin and Nancy Ruffing and Aless{\^a}ndra Borsetti and Angelo Almeida Cardoso and Elizabeth Desjardin and Walter S. Newman and Craig Gerard and Joseph Sodroski},
  journal={Nature},
  year={1996},
  volume={384},
  pages={179-183}
}
FOR efficient entry into target cells, primary macrophage-tropic and laboratory-adapted human immunodeficiency viruses type 1 (HIV-1) require particular chemokine receptors, CCR-5 and CXCR-4, respectively, as well as the primary receptor CD4 (refs 1–6). Here we show that a complex of gp120, the exterior envelope glycoprotein, of macrophage-tropic primary HIV-1 and soluble CD4 interacts specifically with CCR-5 and inhibits the binding of the natural CCR-5 ligands, macrophage inflammatory protein… CONTINUE READING
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