CD4-expressing cells are early mediators of the innate immune system during sepsis.

@article{Martignoni2008CD4expressingCA,
  title={CD4-expressing cells are early mediators of the innate immune system during sepsis.},
  author={Andr{\'e} Martignoni and Johannes Tschoep and Holly S. Goetzman and Lisa G Choi and Maria D Reid and Jay A Johannigman and Alex B. Lentsch and Charles C Caldwell},
  journal={Shock},
  year={2008},
  volume={29 5},
  pages={
          591-7
        }
}
It is well established that the immune response to sepsis is mediated by leukocytes associated with the innate immune system. However, there is an emerging view that T lymphocytes can also mediate this response. Here, we observed a significant depletion of both CD4 and CD8 T cells in human patients after blunt trauma. To determine what effect the loss of these cells may have during a subsequent infection, we obtained CD4- and CD8-deficient mice and subjected them to cecal ligation and puncture… CONTINUE READING

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