CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse

@article{Li2004CD4ET,
  title={CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse},
  author={Qi-jing Li and Aaron R. Dinner and Shuyan Qi and Darrell J Irvine and Johannes B. Huppa and Mark M. Davis and Arup K. Chakraborty},
  journal={Nature Immunology},
  year={2004},
  volume={5},
  pages={791-799}
}
How T cells respond with extraordinary sensitivity to minute amounts of agonist peptide and major histocompatibility complex (pMHC) molecules on the surface of antigen-presenting cells bearing large numbers of endogenous pMHC molecules is not understood. Here we present evidence that CD4 affects the responsiveness of T helper cells by controlling spatial localization of the tyrosine kinase Lck in the synapse. This finding, as well as further in silico and in vitro experiments, led us to develop… CONTINUE READING
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