CD4 engagement induces Fas antigen-dependent apoptosis of T cells in vivo.

Abstract

CD4 is a T lymphocyte receptor for major histocompatibility complex class II antigens. It is referred to as coreceptor because it synergizes with the T cell receptor for antigen when both receptors become engaged simultaneously. We show here in mice that when engaged by antibody independently of the T cell antigen receptor, CD4 induces T cells to undergo… (More)

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@article{Wang1994CD4EI, title={CD4 engagement induces Fas antigen-dependent apoptosis of T cells in vivo.}, author={Zhong Wang and Amruta Dudhane and Th W Orlikowsky and Kareem Clarke and Xuemin Li and Zbigniew Darzynkiewicz and Michael K. Hoffmann}, journal={European journal of immunology}, year={1994}, volume={24 7}, pages={1549-52} }