CD4-dependent and CD4-independent HIV-2: consequences for neutralization.

@article{Thomas2003CD4dependentAC,
  title={CD4-dependent and CD4-independent HIV-2: consequences for neutralization.},
  author={Elaine R Thomas and Christine F Shotton and Robin A Weiss and Paul R. Clapham and {\'A}ine McKnight},
  journal={AIDS},
  year={2003},
  volume={17 3},
  pages={291-300}
}
BACKGROUND HIV-2 is less pathogenic than HIV-1. In contrast to HIV-1, many isolates of HIV-2, including primary isolates, can infect cells independently of CD4. OBJECTIVE To compare the sensitivity of CD4-dependent and CD4-independent isolates of HIV-2 to antibody-mediated neutralization. METHODS The neutralization sensitivity of CD4-dependent and CD4-independent molecular clones of HIV-2 to a panel of HIV-2-positive serum samples was tested. Monoclonal antibodies to various epitopes across… CONTINUE READING

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