CD4 cell eligibility thresholds: an analysis of the time to antiretroviral treatment in HIV-1 seroconverters.

@article{Minga2011CD4CE,
  title={CD4 cell eligibility thresholds: an analysis of the time to antiretroviral treatment in HIV-1 seroconverters.},
  author={Albert Kla Minga and Charlotte Lewden and Delphine Gabillard and Germain I Bomisso and Thomas-d'aquin Toni and Arlette A Emi{\`e}me and Vincent Yapo and Andr{\'e} Inwoley and Roger Salamon and Xavier Anglaret},
  journal={AIDS},
  year={2011},
  volume={25 6},
  pages={
          819-23
        }
}
BACKGROUND WHO recommends initiating combination antiretroviral treatment at the minimal CD4 cell threshold of 350 cells/μl. In sub-Saharan Africa, the time for a recently infected patient to reach this threshold is unclear. METHOD We estimated the probability of reaching different CD4 cell thresholds over time in the ANRS 1220 cohort of HIV-1 seroconverters in Côte d'Ivoire. CD4 cell slopes were estimated using a mixed linear model. Probabilities of crossing the 350 and 500 cells/μl CD4 cell… CONTINUE READING
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