CD4 augments the response of a T cell to agonist but not to antagonist ligands.

@article{Hampl1997CD4AT,
  title={CD4 augments the response of a T cell to agonist but not to antagonist ligands.},
  author={J S Hampl and Yueh-hsiu Chien and Mark M. Davis},
  journal={Immunity},
  year={1997},
  volume={7 3},
  pages={379-85}
}
The recognition of peptide variants by the T cell receptor (TCR) has revealed a wide range of possible responses. Here, using a series of CD4+ and CD4- variants of the same T cell hybridoma, we find that while the expression of CD4 converts weak agonists into full agonists, none of the antagonist peptides are efficiently recognized as agonists. Furthermore, in antagonist assays, little difference can be seen in the response of CD4+ and CD4- T cells. Together with previous work showing a marked… CONTINUE READING

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