CD4 and signal transduction.

@article{Ravichandran1996CD4AS,
  title={CD4 and signal transduction.},
  author={Kodi S Ravichandran and Tassie L. Collins and Steven J. Burakoff},
  journal={Current topics in microbiology and immunology},
  year={1996},
  volume={205},
  pages={
          47-62
        }
}
The CD4 molecule plays an important role in the development of CD4+T lymphocytes and it also acts as a coreceptor to enhance responses mediated via the TCR. It is now established that CD4 functions both as an adhesion molecule favoring the T cell: APC interaction and as a signaling molecule. The coreceptor function mediated via CD4 depends on its association with Lck, a src-family tyrosine kinase. Lck, while interacting via its unique NH2-terminal domain with CD4, also interacts via its SH2 and… CONTINUE READING

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