CD4 and major histocompatibility complex class I downregulation by the human immunodeficiency virus type 1 nef protein in pediatric AIDS progression.

@article{Casartelli2003CD4AM,
  title={CD4 and major histocompatibility complex class I downregulation by the human immunodeficiency virus type 1 nef protein in pediatric AIDS progression.},
  author={Nicoletta Casartelli and Gigliola Di Matteo and Marina Potest{\`a} and Paolo Emilio Rossi and Margherita Doria},
  journal={Journal of virology},
  year={2003},
  volume={77 21},
  pages={
          11536-45
        }
}
The human immunodeficiency virus type 1 (HIV-1) nef gene is a crucial determinant in AIDS disease progression. Although several in vitro activities have been attributed to the Nef protein, identifying the one critical for in vivo pathogenicity remains elusive. In this study, we examined a large number of nef alleles derived at various time points from 13 perinatally infected children showing different progression rates: six nonprogressors (NPs), three slow progressors (SPs), and four rapid… CONTINUE READING

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