CD4 and CCR5 constitutively interact at the plasma membrane of living cells: a confocal fluorescence resonance energy transfer-based approach.

@article{Gaibelet2006CD4AC,
  title={CD4 and CCR5 constitutively interact at the plasma membrane of living cells: a confocal fluorescence resonance energy transfer-based approach.},
  author={G{\'e}rald Gaibelet and Thierry Planchenault and Serge Mazeres and Fabrice Dumas and Fernando Arenzana-Seisdedos and Andr{\'e} Lopez and Bernard Lagane and Françoise Bachelerie},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 49},
  pages={37921-9}
}
Human immunodeficiency virus entry into target cells requires sequential interactions of the viral glycoprotein envelope gp120 with CD4 and chemokine receptors CCR5 or CXCR4. CD4 interaction with the chemokine receptor is suggested to play a critical role in this process but to what extent such a mechanism takes place at the surface of target cells remains elusive. To address this issue, we used a confocal microspectrofluorimetric approach to monitor fluorescence resonance energy transfer at… CONTINUE READING

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