CD4-Transgenic Zebrafish Reveal Tissue-Resident Th2- and Regulatory T Cell–like Populations and Diverse Mononuclear Phagocytes

@inproceedings{Dee2016CD4TransgenicZR,
  title={CD4-Transgenic Zebrafish Reveal Tissue-Resident Th2- and Regulatory T Cell–like Populations and Diverse Mononuclear Phagocytes},
  author={Christopher T Dee and Raghavendar T Nagaraju and Emmanouil I Athanasiadis and Caroline C Gray and Laura Fernandez del Ama and Simon Andrew Johnston and Christopher J Secombes and Ana Cvejic and Adam F L Hurlstone},
  booktitle={Journal of immunology},
  year={2016}
}
CD4+ T cells are at the nexus of the innate and adaptive arms of the immune system. However, little is known about the evolutionary history of CD4+ T cells, and it is unclear whether their differentiation into specialized subsets is conserved in early vertebrates. In this study, we have created transgenic zebrafish with vibrantly labeled CD4+ cells allowing us to scrutinize the development and specialization of teleost CD4+ leukocytes in vivo. We provide further evidence that CD4+ macrophages… CONTINUE READING
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