CD4+ T lymphocytes mediate in vivo clearance of plasmid DNA vaccine antigen expression and potentiate CD8+ T-cell immune responses.

Abstract

There is evidence that the limited immunogenicity of plasmid DNA vaccines is the result, at least in part, of the rapid clearance of vaccine antigen expression by antigen-specific immune responses. However, the cell types responsible for the clearance of plasmid DNA vaccine antigens are not known. Here we demonstrate that macrophages, NK cells, and CD8(+) T… (More)
DOI: 10.1182/blood-2008-06-165803

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@article{GeibenLynn2008CD4TL, title={CD4+ T lymphocytes mediate in vivo clearance of plasmid DNA vaccine antigen expression and potentiate CD8+ T-cell immune responses.}, author={Ralf Geiben-Lynn and John R Greenland and Kwesi Frimpong-Boateng and Nico van van Rooijen and Avi-Hai Hovav and Norman L. Letvin}, journal={Blood}, year={2008}, volume={112 12}, pages={4585-90} }