CD4-T-lymphocyte interactions with pneumolysin and pneumococci suggest a crucial protective role in the host response to pneumococcal infection.

@article{Kadioglu2004CD4TlymphocyteIW,
  title={CD4-T-lymphocyte interactions with pneumolysin and pneumococci suggest a crucial protective role in the host response to pneumococcal infection.},
  author={Aras Kadioglu and William R. Coward and M. Joseph Colston and Colin R. A. Hewitt and P. W. Andrew},
  journal={Infection and immunity},
  year={2004},
  volume={72 5},
  pages={2689-97}
}
Previously, we had shown that T cells accumulated in peribronchiolar and perivascular areas of lungs soon after intranasal infection with Streptococcus pneumoniae. We have now presented new evidence, using major histocompatibility class II-deficient mice, that CD4 cells are important for early protective immunity. In addition, we have also shown that a population of human CD4 cells migrates towards pneumococci and that in vivo-passaged pneumococci are substantially more potent at inducing… CONTINUE READING

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