CD4 T follicular helper cell dynamics during SIV infection.

@article{Petrovas2012CD4TF,
  title={CD4 T follicular helper cell dynamics during SIV infection.},
  author={Constantinos Petrovas and Takuya Yamamoto and Michael Y Gerner and Kristin L. Boswell and Kaska Wloka and Emily C. Smith and David R. Ambrozak and Netanya G. Sandler and Katherina J Timmer and Xiaoyong Sun and Li Pan and Amanda C. Poholek and S. S. S. Nageshwara Rao and Jason M. Brenchley and S. Munir Alam and Georgia D. Tomaras and Mario Roederer and Daniel C. Douek and Robert A. Seder and Ronald N. Germain and Elias K Haddad and Richard A. Koup},
  journal={The Journal of clinical investigation},
  year={2012},
  volume={122 9},
  pages={3281-94}
}
CD4 T follicular helper (TFH) cells interact with and stimulate the generation of antigen-specific B cells. TFH cell interaction with B cells correlates with production of SIV-specific immunoglobulins. However, the fate of TFH cells and their participation in SIV-induced antibody production is not well understood. We investigated the phenotype, function, location, and molecular signature of TFH cells in rhesus macaques. Similar to their human counterparts, TFH cells in rhesus macaques… CONTINUE READING
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