CD4 T cells promote tissue inflammation via CD40 signaling without de novo activation in a murine model of liver ischemia/reperfusion injury.

@article{Shen2009CD4TC,
  title={CD4 T cells promote tissue inflammation via CD40 signaling without de novo activation in a murine model of liver ischemia/reperfusion injury.},
  author={Xiuda Shen and Yue Wang and Feng Gao and Feng Ren and Ronald W Busuttil and Jerzy W. Kupiec-Weglinski and Yuan Zhai},
  journal={Hepatology},
  year={2009},
  volume={50 5},
  pages={1537-46}
}
UNLABELLED Although the role of CD4 T cells in tissue inflammation and organ injury resulting from ischemia and reperfusion injury (IRI) has been well documented, it remains unclear how CD4 T cells are activated and function in the absence of a specific antigen (Ag). We used a murine liver warm IRI model to determine first whether de novo Ag-specific CD4 T cell activation was required and then what its functional mechanism was. The critical role of CD4 T cells in liver immune activation against… CONTINUE READING

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