CD4+ T cells from human neonates and infants are poised spontaneously to run a nonclassical IL-4 program.

Abstract

Senescence or biological aging impacts a vast variety of molecular and cellular processes. To date, it is unknown whether CD4(+) Th cells display an age-dependent bias for development into specific subpopulations. In this study, we show the appearance of a distinct CD4(+) T cell subset expressing IL-4 at an early stage of development in infant adenoids and… (More)
DOI: 10.4049/jimmunol.1302539

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@article{Hebel2014CD4TC, title={CD4+ T cells from human neonates and infants are poised spontaneously to run a nonclassical IL-4 program.}, author={Katrin Hebel and Soenke Weinert and Benno Kuropka and Julienne Knolle and Bernhard Kosak and Gerhard Jorch and Christoph Arens and Eberhard Krause and R{\"{u}diger Braun-Dullaeus and Monika C Brunner-Weinzierl}, journal={Journal of immunology}, year={2014}, volume={192 11}, pages={5160-70} }