CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly.

@article{Haynes2003CD4TC,
  title={CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly.},
  author={Laura Haynes and Sheri M. Eaton and Eve M. Burns and Troy D. Randall and Susan L Swain},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 25},
  pages={15053-8}
}
Age-related declines in immune function have an impact on both primary and memory responses. In this study, we have examined the ability of naive CD4 T cells from young and aged T cell receptor transgenic mice to establish functional memory. We found that memory cells generated from young CD4 T cells responded well to antigen, even a year after generation, whereas memory cells derived from CD4 T cells from aged mice responded poorly both ex vivo and in vivo. Memory cells generated from aged… CONTINUE READING

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