CD4 T-cell immunotherapy for chronic viral infections and cancer.


During chronic infections and cancer, T cells progressively lose function and become exhausted. However, effective T-cell responses are necessary to ultimately control viral infections and tumors. Hence, strategies that either restore endogenous immune responses or provide functional T cells by adoptive immunotherapy need to be explored. CD8 T cells play a prominent role in viral infections, as well as cancer, but CD4 T cells are necessary to support CD8 T-cell function. In addition, CD4 T cells exert direct effector functions, induce optimal B-cell responses and orchestrate innate immunity. Therefore, we propose that adoptive transfer strategies should exploit CD4 T cells alone or in combination with CD8 T cells, for the treatment of chronic infections and cancer. Furthermore, since adoptively transferred cells are subject to exhaustion, combining adoptive transfer therapy with immunotherapies that inhibit T-cell exhaustion should maximize the longevity and success rate of responses.

DOI: 10.2217/imt.13.91
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@article{Kamphorst2013CD4TI, title={CD4 T-cell immunotherapy for chronic viral infections and cancer.}, author={Alice O Kamphorst and Rafi Ahmed}, journal={Immunotherapy}, year={2013}, volume={5 9}, pages={975-87} }