CD4 T-cell hyperactivation and susceptibility to cell death determine poor CD4 T-cell recovery during suppressive HAART.

@article{Massanella2010CD4TH,
  title={CD4 T-cell hyperactivation and susceptibility to cell death determine poor CD4 T-cell recovery during suppressive HAART.},
  author={Marta Massanella and Eug{\`e}nia Negredo and N{\'u}ria P{\'e}rez-{\'A}lvarez and Jordi Puig and Raul Ruiz-Hern{\'a}ndez and Margarita Bofill and Bonaventura Clotet and Julia C. Blanco},
  journal={AIDS},
  year={2010},
  volume={24 7},
  pages={959-68}
}
BACKGROUND The failure to increase CD4 T-cell counts in some HAART-treated HIV-infected patients with satisfactory virological responses has been related to low CD4 T-cell production, high turnover and death. However, the relative contribution of these factors is still unclear, strongly limiting the definition of appropriate therapeutic strategies for these patients. METHODS A cross-sectional study was designed to evaluate the contribution of thymic activity, microbial translocation, cellular… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 38 extracted citations

Similar Papers

Loading similar papers…