CD4 T-Cell Subsets in Malaria: TH1/TH2 Revisited

  title={CD4 T-Cell Subsets in Malaria: TH1/TH2 Revisited},
  author={Dami{\'a}n P{\'e}rez-Mazliah and Jean Langhorne},
  booktitle={Front. Immunol.},
CD4(+) T-cells have been shown to play a central role in immune control of infection with Plasmodium parasites. At the erythrocytic stage of infection, IFN-γ production by CD4(+) T-cells and CD4(+) T-cell help for the B-cell response are required for control and elimination of infected red blood cells. CD4(+) T-cells are also important for controlling Plasmodium pre-erythrocytic stages through the activation of parasite-specific CD8(+) T-cells. However, excessive inflammatory responses… CONTINUE READING
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